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A recent study  has shownthat the trio: DNA-PK, ATM, and ATR together downregulate p53-RPA binding.DNA-PK phosphorylates RPA at S46, and ATM/ATR phosphorylates p53 at S37 (pre-ceded by S15 phosphorylation as discussed above) causing the release of p53 andRPA from the p53-RPA complex and thereby allowing RPA to fulll its normal rolein facilitating HRR.